Ozonating coffee enemas combines two powerful therapies. The coffee stimulates hepatic glutathione S transferase, upregulating detoxification pathways in the liver. It also increases glutathione Coffee Enema and Erectile Dysfunction: What the Evidence Actually Shows Coffee enemas probably won't detox your system they're more likely to cause you serious damage Coffee Enema and Erectile Dysfunction: What the Evidence Actually Shows Coffee Consumption and Oxidative Stress: A Review of Human Intervention Studies Coffee Enemas Doctor Verena